{"symbol":"IMPDH1","synonyms":["SWSS2608","RP10","IMPDH-I","LCA11","IMPD","IMPD1"],"name":"IMP (inosine 5\u0027-monophosphate) dehydrogenase 1","description":"The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5\u0027-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]","ncbiEntrezGeneId":3614,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3614","proteins":[{"symbol":"IMDH1_HUMAN","href":"/api/1.0/protein/IMDH1_HUMAN"}],"hgncRootFamilies":[]}