{"symbol":"INCENP","synonyms":[],"name":"inner centromere protein antigens 135/155kDa","description":"In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and \u0027passenger,\u0027 or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term \u0027passenger proteins\u0027 encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":3619,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3619","proteins":[{"symbol":"INCE_HUMAN","href":"/api/1.0/protein/INCE_HUMAN"}],"hgncRootFamilies":[]}