{"symbol":"IRAK3","synonyms":["IRAKM","ASRT5"],"name":"interleukin-1 receptor-associated kinase 3","description":"This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]","ncbiEntrezGeneId":11213,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11213","proteins":[{"symbol":"IRAK3_HUMAN","href":"/api/1.0/protein/IRAK3_HUMAN"}],"hgncRootFamilies":[]}