{"symbol":"IRF3","synonyms":["IIAE7"],"name":"interferon regulatory factor 3","description":"This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]","ncbiEntrezGeneId":3661,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3661","proteins":[{"symbol":"IRF3_HUMAN","href":"/api/1.0/protein/IRF3_HUMAN"}],"hgncRootFamilies":[]}