{"symbol":"IRF4","synonyms":["LSIRF","MUM1","SHEP8","NF-EM5"],"name":"interferon regulatory factor 4","description":"The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]","ncbiEntrezGeneId":3662,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3662","proteins":[{"symbol":"IRF4_HUMAN","href":"/api/1.0/protein/IRF4_HUMAN"}],"hgncRootFamilies":[]}