{"symbol":"IRF5","synonyms":["SLEB10"],"name":"interferon regulatory factor 5","description":"This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]","ncbiEntrezGeneId":3663,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3663","proteins":[{"symbol":"IRF5_HUMAN","href":"/api/1.0/protein/IRF5_HUMAN"}],"hgncRootFamilies":[]}