{"symbol":"IRF8","synonyms":["IRF-8","ICSBP","IMD32B","ICSBP1","H-ICSBP","IMD32A"],"name":"interferon regulatory factor 8","description":"Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3394,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3394","proteins":[{"symbol":"IRF8_HUMAN","href":"/api/1.0/protein/IRF8_HUMAN"}],"hgncRootFamilies":[]}