{"symbol":"IRGM","synonyms":["LRG47","IRGM1","LRG-47","IFI1"],"name":"immunity-related GTPase family, M","description":"This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn\u0027s disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]","ncbiEntrezGeneId":345611,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/345611","proteins":[{"symbol":"IRGM_HUMAN","href":"/api/1.0/protein/IRGM_HUMAN"}],"hgncRootFamilies":[]}