{"symbol":"IRS1","synonyms":["HIRS-1"],"name":"insulin receptor substrate 1","description":"This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]","ncbiEntrezGeneId":3667,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3667","proteins":[{"symbol":"IRS1_HUMAN","href":"/api/1.0/protein/IRS1_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}