{"symbol":"ISG15","synonyms":["UCRP","IFI15","IMD38","HUCRP","IP17","G1P2"],"name":"ISG15 ubiquitin-like modifier","description":"The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]","ncbiEntrezGeneId":9636,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9636","proteins":[{"symbol":"ISG15_HUMAN","href":"/api/1.0/protein/ISG15_HUMAN"}],"hgncRootFamilies":[]}