{"symbol":"ITGA3","synonyms":["CD49C","VCA-2","GAPB3","ILNEB","MSK18","VLA3A","GAP-B3","VL3A"],"name":"integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)","description":"The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":3675,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3675","proteins":[{"symbol":"ITA3_HUMAN","href":"/api/1.0/protein/ITA3_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Integrins (ITG)","href":"/api/1.0/gene_family/Integrins+%28ITG%29"}]}