{"symbol":"ITGA5","synonyms":["VLA5A","FNRA","VLA-5","CD49E"],"name":"integrin, alpha 5 (fibronectin receptor, alpha polypeptide)","description":"The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":3678,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3678","proteins":[{"symbol":"ITA5_HUMAN","href":"/api/1.0/protein/ITA5_HUMAN"}],"hgncRootFamilies":[{"name":"Integrins (ITG)","href":"/api/1.0/gene_family/Integrins+%28ITG%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}