{"symbol":"ITGAE","synonyms":["HUMINAE","CD103"],"name":"integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)","description":"Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3682,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3682","proteins":[{"symbol":"ITAE_HUMAN","href":"/api/1.0/protein/ITAE_HUMAN"}],"hgncRootFamilies":[{"name":"Integrins (ITG)","href":"/api/1.0/gene_family/Integrins+%28ITG%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}