{"symbol":"ITGAV","synonyms":["VNRA","VTNR","CD51","MSK8"],"name":"integrin, alpha V","description":"The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":3685,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3685","proteins":[{"symbol":"ITAV_HUMAN","href":"/api/1.0/protein/ITAV_HUMAN"}],"hgncRootFamilies":[{"name":"Integrins (ITG)","href":"/api/1.0/gene_family/Integrins+%28ITG%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}