{"symbol":"ITM2B","synonyms":["ABRI","BRI2","IMBRI2","BRI","E25B","RDGCA","BRICD2B","E3-16","FBD"],"name":"integral membrane protein 2B","description":"Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":9445,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9445","proteins":[{"symbol":"ITM2B_HUMAN","href":"/api/1.0/protein/ITM2B_HUMAN"}],"hgncRootFamilies":[{"name":"BRICHOS domain containing (BRICD)","href":"/api/1.0/gene_family/BRICHOS+domain+containing+%28BRICD%29"}]}