{"symbol":"ITPKA","synonyms":["IP3KA","IP3-3KA"],"name":"inositol-trisphosphate 3-kinase A","description":"Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]","ncbiEntrezGeneId":3706,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3706","proteins":[{"symbol":"IP3KA_HUMAN","href":"/api/1.0/protein/IP3KA_HUMAN"}],"hgncRootFamilies":[]}