{"symbol":"ITPR3","synonyms":["IP3R3"],"name":"inositol 1,4,5-trisphosphate receptor, type 3","description":"This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]","ncbiEntrezGeneId":3710,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3710","proteins":[{"symbol":"ITPR3_HUMAN","href":"/api/1.0/protein/ITPR3_HUMAN"}],"hgncRootFamilies":[{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"},{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}