{"symbol":"JAG1","synonyms":["JAGL1","CD339","DCHE","AWS","AGS1","HJ1","AGS","AHD"],"name":"jagged 1","description":"The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019]","ncbiEntrezGeneId":182,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/182","proteins":[{"symbol":"JAG1_HUMAN","href":"/api/1.0/protein/JAG1_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}