{"symbol":"JMJD1C","synonyms":["TRIP-8","KDM3C","TRIP8"],"name":"jumonji domain containing 1C","description":"The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]","ncbiEntrezGeneId":221037,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/221037","proteins":[{"symbol":"JHD2C_HUMAN","href":"/api/1.0/protein/JHD2C_HUMAN"}],"hgncRootFamilies":[]}