{"symbol":"KALRN","synonyms":["ARHGEF24","DUET","HAPIP","CHDS5","DUO"],"name":"kalirin, RhoGEF kinase","description":"Huntington\u0027s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]","ncbiEntrezGeneId":8997,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8997","proteins":[{"symbol":"KALRN_HUMAN","href":"/api/1.0/protein/KALRN_HUMAN"}],"hgncRootFamilies":[{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"},{"name":"Rho guanine nucleotide exchange factors (ARHGEF)","href":"/api/1.0/gene_family/Rho+guanine+nucleotide+exchange+factors+%28ARHGEF%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}