{"symbol":"KARS","synonyms":["KARS1","KRS","DFNB89","CMTRIB","KARS2"],"name":"lysyl-tRNA synthetase","description":"Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3735,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3735","proteins":[{"symbol":"SYK_HUMAN","href":"/api/1.0/protein/SYK_HUMAN"}],"hgncRootFamilies":[{"name":"Aminoacyl tRNA synthetases","href":"/api/1.0/gene_family/Aminoacyl+tRNA+synthetases"}]}