{"symbol":"KAT2B","synonyms":["CAF","P/CAF","PCAF"],"name":"K(lysine) acetyltransferase 2B","description":"CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8850,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8850","proteins":[{"symbol":"KAT2B_HUMAN","href":"/api/1.0/protein/KAT2B_HUMAN"}],"hgncRootFamilies":[{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"}]}