{"symbol":"KAT6B","synonyms":["QUERKOPF","GTPTS","QKF","ZC2HC6B","MYST4","MORF","MOZ2"],"name":"K(lysine) acetyltransferase 6B","description":"The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":23522,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23522","proteins":[{"symbol":"KAT6B_HUMAN","href":"/api/1.0/protein/KAT6B_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"},{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"}]}