{"symbol":"KCNIP3","synonyms":["CSEN","KCHIP3","DREAM"],"name":"Kv channel interacting protein 3, calsenilin","description":"This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":30818,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/30818","proteins":[{"symbol":"CSEN_HUMAN","href":"/api/1.0/protein/CSEN_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"},{"name":"Potassium channel, voltage gated regulatory beta subunits","href":"/api/1.0/gene_family/Potassium+channel%2C+voltage+gated+regulatory+beta+subunits"}]}