{"symbol":"KDM2A","synonyms":["JHDM1A","CXXC8","FBL11","LILINA","FBL7","FBXL11"],"name":"lysine (K)-specific demethylase 2A","description":"This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]","ncbiEntrezGeneId":22992,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22992","proteins":[{"symbol":"KDM2A_HUMAN","href":"/api/1.0/protein/KDM2A_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"},{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"},{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"}]}