{"symbol":"KDM4B","synonyms":["TDRD14B","JMJD2B"],"name":"lysine (K)-specific demethylase 4B","description":"Enables histone H3K36 demethylase activity and histone H3K9me2/H3K9me3 demethylase activity. Predicted to be involved in brain development; chromatin remodeling; and regulation of gene expression. Located in cytosol and nucleoplasm. Implicated in autosomal dominant intellectual developmental disorder; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":23030,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23030","proteins":[{"symbol":"KDM4B_HUMAN","href":"/api/1.0/protein/KDM4B_HUMAN"}],"hgncRootFamilies":[{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"},{"name":"Tudor domain containing (TDRD)","href":"/api/1.0/gene_family/Tudor+domain+containing+%28TDRD%29"}]}