{"symbol":"KDM5B","synonyms":["RBBP2H1A","PPP1R98","RBP2-H1","PLU-1","PLU1","PUT1","CT31","JARID1B","MRT65"],"name":"lysine (K)-specific demethylase 5B","description":"This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]","ncbiEntrezGeneId":10765,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10765","proteins":[{"symbol":"KDM5B_HUMAN","href":"/api/1.0/protein/KDM5B_HUMAN"}],"hgncRootFamilies":[{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}