{"symbol":"KIF7","synonyms":["JBTS12","UNQ340","AGBK"],"name":"kinesin family member 7","description":"This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]","ncbiEntrezGeneId":374654,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/374654","proteins":[{"symbol":"KIF7_HUMAN","href":"/api/1.0/protein/KIF7_HUMAN"}],"hgncRootFamilies":[{"name":"Kinesins (KIF)","href":"/api/1.0/gene_family/Kinesins+%28KIF%29"}]}