{"symbol":"KIRREL3","synonyms":["MRD4","NEPH2","KIRRE","PRO4502"],"name":"kin of IRRE like 3 (Drosophila)","description":"The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]","ncbiEntrezGeneId":84623,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/84623","proteins":[{"symbol":"KIRR3_HUMAN","href":"/api/1.0/protein/KIRR3_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}