{"symbol":"KLF12","synonyms":["AP2REP","AP-2REP","HSPC122"],"name":"Kruppel-like factor 12","description":"Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":11278,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11278","proteins":[{"symbol":"KLF12_HUMAN","href":"/api/1.0/protein/KLF12_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}