{"symbol":"KLHL6","synonyms":[],"name":"kelch-like family member 6","description":"This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]","ncbiEntrezGeneId":89857,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/89857","proteins":[{"symbol":"KLHL6_HUMAN","href":"/api/1.0/protein/KLHL6_HUMAN"}],"hgncRootFamilies":[{"name":"Kelch-like (KLHL)","href":"/api/1.0/gene_family/Kelch-like+%28KLHL%29"},{"name":"BTB (POZ) domain containing (BTBD)","href":"/api/1.0/gene_family/BTB+%28POZ%29+domain+containing+%28BTBD%29"}]}