{"symbol":"KLK2","synonyms":["KLK2A2","HGK-1"],"name":"kallikrein-related peptidase 2","description":"This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]","ncbiEntrezGeneId":3817,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3817","proteins":[{"symbol":"KLK2_HUMAN","href":"/api/1.0/protein/KLK2_HUMAN"}],"hgncRootFamilies":[{"name":"Kallikreins (KLK)","href":"/api/1.0/gene_family/Kallikreins+%28KLK%29"}]}