{"symbol":"KLK7","synonyms":["PRSS6","SCCE","HK7"],"name":"kallikrein-related peptidase 7","description":"This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]","ncbiEntrezGeneId":5650,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5650","proteins":[{"symbol":"KLK7_HUMAN","href":"/api/1.0/protein/KLK7_HUMAN"}],"hgncRootFamilies":[{"name":"Kallikreins (KLK)","href":"/api/1.0/gene_family/Kallikreins+%28KLK%29"},{"name":"Proteases, serine (PRSS)","href":"/api/1.0/gene_family/Proteases%2C+serine+%28PRSS%29"}]}