{"symbol":"KLKB1","synonyms":["PKKD","KLK3"],"name":"kallikrein B, plasma (Fletcher factor) 1","description":"This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]","ncbiEntrezGeneId":3818,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3818","proteins":[{"symbol":"KLKB1_HUMAN","href":"/api/1.0/protein/KLKB1_HUMAN"}],"hgncRootFamilies":[{"name":"Kallikreins (KLK)","href":"/api/1.0/gene_family/Kallikreins+%28KLK%29"}]}