{"symbol":"KLRC1","synonyms":["NKG2A","CD159A","NKG2"],"name":"killer cell lectin-like receptor subfamily C, member 1","description":"Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]","ncbiEntrezGeneId":3821,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3821","proteins":[{"symbol":"NKG2A_HUMAN","href":"/api/1.0/protein/NKG2A_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Killer cell lectin-like receptors (KLR)","href":"/api/1.0/gene_family/Killer+cell+lectin-like+receptors+%28KLR%29"}]}