{"symbol":"KLRC2","synonyms":["NKG2-C","CD159C","NKG2C"],"name":"killer cell lectin-like receptor subfamily C, member 2","description":"Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3822,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3822","proteins":[{"symbol":"NKG2C_HUMAN","href":"/api/1.0/protein/NKG2C_HUMAN"}],"hgncRootFamilies":[{"name":"Killer cell lectin-like receptors (KLR)","href":"/api/1.0/gene_family/Killer+cell+lectin-like+receptors+%28KLR%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}