{"symbol":"KLRC3","synonyms":["NKG2-E","NKG2E"],"name":"killer cell lectin-like receptor subfamily C, member 3","description":"Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3823,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3823","proteins":[{"symbol":"NKG2E_HUMAN","href":"/api/1.0/protein/NKG2E_HUMAN"}],"hgncRootFamilies":[{"name":"Killer cell lectin-like receptors (KLR)","href":"/api/1.0/gene_family/Killer+cell+lectin-like+receptors+%28KLR%29"}]}