{"symbol":"KNSTRN","synonyms":["TRAF4AF1","SKAP","C15ORF23"],"name":"kinetochore-localized astrin/SPAG5 binding protein","description":"Enables microtubule plus-end binding activity and protein homodimerization activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and ruffle. Implicated in actinic keratosis and skin squamous cell carcinoma. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":90417,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/90417","proteins":[{"symbol":"SKAP_HUMAN","href":"/api/1.0/protein/SKAP_HUMAN"}],"hgncRootFamilies":[]}