{"symbol":"KPNA4","synonyms":["SRP3","QIP1","IPOA3"],"name":"karyopherin alpha 4 (importin alpha 3)","description":"The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3840,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3840","proteins":[{"symbol":"IMA3_HUMAN","href":"/api/1.0/protein/IMA3_HUMAN"}],"hgncRootFamilies":[{"name":"Armadillo repeat containing (ARMC)","href":"/api/1.0/gene_family/Armadillo+repeat+containing+%28ARMC%29"},{"name":"Importins (IPO)","href":"/api/1.0/gene_family/Importins+%28IPO%29"}]}