{"symbol":"KREMEN1","synonyms":["KREMEN","ECTD13","KRM1"],"name":"kringle containing transmembrane protein 1","description":"This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021]","ncbiEntrezGeneId":83999,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/83999","proteins":[{"symbol":"KREM1_HUMAN","href":"/api/1.0/protein/KREM1_HUMAN"}],"hgncRootFamilies":[]}