{"symbol":"KRT78","synonyms":["K78","K5B","CK-78","KB40"],"name":"keratin 78, type II","description":"This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":196374,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/196374","proteins":[{"symbol":"K2C78_HUMAN","href":"/api/1.0/protein/K2C78_HUMAN"}],"hgncRootFamilies":[{"name":"Intermediate filaments","href":"/api/1.0/gene_family/Intermediate+filaments"}]}