{"symbol":"LARS","synonyms":["HSPC192","ILFS1","LRS","PIG44","LARS1","LEUS","LFIS","RNTLS","HR025CL"],"name":"leucyl-tRNA synthetase","description":"This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]","ncbiEntrezGeneId":51520,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51520","proteins":[{"symbol":"SYLC_HUMAN","href":"/api/1.0/protein/SYLC_HUMAN"}],"hgncRootFamilies":[{"name":"Aminoacyl tRNA synthetases","href":"/api/1.0/gene_family/Aminoacyl+tRNA+synthetases"}]}