{"symbol":"LARS1","synonyms":[],"name":"leucyl-tRNA synthetase 1","description":"This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]","ncbiEntrezGeneId":51520,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gove/gene/51520","proteins":[],"hgncRootFamilies":[]}