{"symbol":"LATS2","synonyms":["KPM"],"name":"large tumor suppressor kinase 2","description":"This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":26524,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26524","proteins":[{"symbol":"LATS2_HUMAN","href":"/api/1.0/protein/LATS2_HUMAN"}],"hgncRootFamilies":[]}