{"symbol":"LBP","synonyms":["BPIFD2"],"name":"lipopolysaccharide binding protein","description":"The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]","ncbiEntrezGeneId":3929,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3929","proteins":[{"symbol":"LBP_HUMAN","href":"/api/1.0/protein/LBP_HUMAN"}],"hgncRootFamilies":[{"name":"BPI fold containing (BPIF)","href":"/api/1.0/gene_family/BPI+fold+containing+%28BPIF%29"}]}