{"symbol":"LCP1","synonyms":["CP64","L-PLASTIN","HEL-S-37","PLS2","LPL","LC64P"],"name":"lymphocyte cytosolic protein 1 (L-plastin)","description":"Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3936,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3936","proteins":[{"symbol":"PLSL_HUMAN","href":"/api/1.0/protein/PLSL_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}