{"symbol":"LDHB","synonyms":["LDHBD","TRG-5","LDH-B","HEL-S-281","LDH-H"],"name":"lactate dehydrogenase B","description":"This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]","ncbiEntrezGeneId":3945,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3945","proteins":[{"symbol":"LDHB_HUMAN","href":"/api/1.0/protein/LDHB_HUMAN"}],"hgncRootFamilies":[]}