{"symbol":"LEFTY1","synonyms":["LEFTB","LEFTYB"],"name":"left-right determination factor 1","description":"This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]","ncbiEntrezGeneId":10637,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10637","proteins":[{"symbol":"LFTY1_HUMAN","href":"/api/1.0/protein/LFTY1_HUMAN"}],"hgncRootFamilies":[]}