{"symbol":"LEMD3","synonyms":["MAN1"],"name":"LEM domain containing 3","description":"This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]","ncbiEntrezGeneId":23592,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23592","proteins":[{"symbol":"MAN1_HUMAN","href":"/api/1.0/protein/MAN1_HUMAN"}],"hgncRootFamilies":[]}