{"symbol":"LGI1","synonyms":["EPT","EPITEMPIN","ADPEAF","ADLTE","ETL1","ADPAEF","IB1099"],"name":"leucine-rich, glioma inactivated 1","description":"This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]","ncbiEntrezGeneId":9211,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9211","proteins":[{"symbol":"LGI1_HUMAN","href":"/api/1.0/protein/LGI1_HUMAN"}],"hgncRootFamilies":[]}